Rhodopsin Antibody (RHO)| F45215-0.08ML

Rhodopsin Antibody (RHO)| F45215-0.08ML | Gentaur UK, US & Europe Distribution

Background: Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form, which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Primate

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the RHO antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This RHO antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 310-339 from human Rhodopsin was used as the immunogen for this RHO antibody.

Storage: Aliquot the RHO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A