RI-1 | B1823

RI-1 is a potent and selective inhibitor of RAD51 (IC₅₀ = 5-30 μM). It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells. Potentiates the killing of glioblastoma cells by ionizing radiation and alkylating drugs.

RI-1 is a potent and selective inhibitor of RAD51 (IC₅₀ = 5-30 μM). It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells. Potentiates the killing of glioblastoma cells by ionizing radiation and alkylating drugs.

B1823 | RI-1 DataSheet

Alternate Name/Synonyms: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Appearance: Yellow solid

Formulation: N/A

CAS Number: 415713-60-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₄H₁₁Cl₃N₂O₃

Molecular Weight: 361.61

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective inhibitor of RAD51

MDL Number: N/A

PubChem CID: 1074953

SMILES: C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl

InChi: ChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2

InChi Key: MWSUIZKGNWELRF-UHFFFAOYSA-N