RIC8A Antibody (Center) [APR13102G]

RIC8A Antibody (Center) [APR13102G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RIC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the Central region of human RIC8A.

Cellular Localisation: Cytoplasm. Cell membrane. Note=Colocalizes with RIC8A in CA2 hippocampal neurons Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity) .

Molecular Weight: 59710

Clone: Polyclonal

Gene Name: RIC8A

Gene ID: 60626

Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) - alpha-GDP complex (By similarity) . Also acts as an activator for G (q) - alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Synembryn-A, Protein Ric-8A, RIC8A