Rigosertib | 9482

Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC₅₀ > 0.1 mM).

Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC₅₀ > 0.1 mM).

9482 | Rigosertib DataSheet

Alternate Name/Synonyms: Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate; ON-01910

Appearance: White solid

Formulation: N/A

CAS Number: 1225497-78-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₄NNaO₈S

Molecular Weight: 473.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, specific PLK1 (Polo -Like Kinase 1) inhibitor

MDL Number: N/A

PubChem CID: 23696523

SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

InChi: InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;

InChi Key: VLQLUZFVFXYXQE-USRGLUTNSA-M