RIOK1 Antibody (N-term) [AMM07632G]

RIOK1 Antibody (N-term) [AMM07632G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RIOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-156 amino acids from the N-terminal region of human RIOK1.

Cellular Localisation: Cytoplasm, cytosol.

Molecular Weight: 65583

Clone: Polyclonal

Gene Name: RIOK1 (HGNC:18656)

Gene ID: 83732

Function: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790) . The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity) . Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity) . The catalytic activity regulates its dynamic association with the 40S subunit (By similarity) . In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: Serine/threonine-protein kinase RIO1, RIO kinase 1, RIOK1