RIOK3 Antibody (Center) [AMM07615G]

RIOK3 Antibody (Center) [AMM07615G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RIOK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 146-179 amino acids from the Central region of human RIOK3.

Cellular Localisation: Cytoplasm.

Molecular Weight: 59093

Clone: Polyclonal

Gene Name: RIOK3

Gene ID: 8780

Function: Involved in regulation of type I interferon (IFN) -dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708) . Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883) . Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502) . May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843) .

Summary: Tissue Location: Widely expressed..

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Serine/threonine-protein kinase RIO3, RIO kinase 3, sudD homolog, RIOK3, SUDD