LBD
RIOK3 Antibody (Center) [AMM07615G]
- SKU:
- LBD-AMM07615G
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Description
RIOK3 Antibody (Center) [AMM07615G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This RIOK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 146-179 amino acids from the Central region of human RIOK3.
Cellular Localisation: Cytoplasm.
Molecular Weight: 59093
Clone: Polyclonal
Gene Name: RIOK3
Gene ID: 8780
Function: Involved in regulation of type I interferon (IFN) -dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708) . Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883) . Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502) . May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843) .
Summary: Tissue Location: Widely expressed..
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Serine/threonine-protein kinase RIO3, RIO kinase 3, sudD homolog, RIOK3, SUDD