RKI-1447 | 2472

A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors.

RKI-1447 is a highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2).

2472 | RKI-1447 DataSheet

Alternate Name/Synonyms: N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1342278-01-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄N₄O₂S

Molecular Weight: 326.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly potent ROCK1 and ROCK2 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(NCC1=CC=CC(O)=C1)NC2=NC(C3=CC=NC=C3)=CS2

InChi: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)

InChi Key: GDVRVPIXWXOKQO-UHFFFAOYSA-N