Description
A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors.
RKI-1447 is a highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2).
Alternate Name/Synonyms: N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1342278-01-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₄N₄O₂S
Molecular Weight: 326.37
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly potent ROCK1 and ROCK2 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(NCC1=CC=CC(O)=C1)NC2=NC(C3=CC=NC=C3)=CS2
InChi: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChi Key: GDVRVPIXWXOKQO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |