RLN3 Antibody | 8181

RLN3 Antibody | 8181 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (89%) , Rat: (84%)

Immunogen: RLN3 antibody was raised against a 19 amino acid peptide near the center of human RLN3.
The immunogen is located within amino acids 80 - 130 of RLN3.

Research Area: Signal Transduction, Neuroscience

Tested Application: E, WB, IHC-P, IF

Application: RLN3 antibody can be used for detection of RLN3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: RLN3 antibody is human specific. RLN3 antibody is predicted to not cross-react with other members of the Relaxin protein family.

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: Cat. No. 10-301 - Human Brain Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 16 kDa
Observed: 16 kDa

Validation: N/A

Isoform: N/A

Purification: RLN3 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: RLN3 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: RLN3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Relaxin-3, RXN3, H3, ZINS4, INSL7

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Relaxin-3 (RLN3) is a member of Relaxin family, a group of endocrine and autocrine/paracrine hormones that belong to the insulin gene superfamily (1, 2) . RLN3 can bind to and activate three relaxin-family peptide receptors: RXFP1, RXFP3, and RXFP4 (3) . In contrast to the widespread expression of the related proteins RLN1 and RLN2, RLN3 is predominantly expressed in brain and to a lesser extent in the thymus, kidney and spleen (1) . RLN3 has been suggested to play a role in feeding, metabolism, stress, arousal, learning, and memory (4) .