RMC-4550 | B2752

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM). RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2.

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM). RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2.

B2752 | RMC-4550 DataSheet

Alternate Name/Synonyms: RMC4550,(3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol

Appearance: White to off-white solid

Formulation:

CAS Number: 2172651-73-7

Structure Available?:

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₆Cl₂N₄O₂

Molecular Weight: 437.36

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >100 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, selective and allosteric SHP2 inhibitor

MDL Number:

PubChem CID: 134183206

SMILES: ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)N=C2C)=CC=C1

InChi: InChI=1S/C21H26Cl2N4O2/c1-12-18(14-4-3-5-15(22)17(14)23)26-16(10-28)20(25-12)27-8-6-21(7-9-27)11-29-13(2)19(21)24/h3-5,13,19,28H,6-11,24H2,1-2H3/t13-,19+/m0/s1

InChi Key: ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)N=C2C)=CC=C1