RMND5B Antibody (C-term) [APR05074G]

RMND5B Antibody (C-term) [APR05074G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RMND5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the C-terminal region of human RMND5B.

Cellular Localisation: Cytoplasm, cytosol.

Molecular Weight: 44414

Clone: Polyclonal

Gene Name: RMND5B

Gene ID: 64777

Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972) . Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972) . The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Protein RMD5 homolog B, RMND5B