RN 1 dihydrochloride | B2080

RN 1 dihydrochloride is a potent, cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Displays selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice.

RN 1 dihydrochloride is a potent, cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Displays selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice.

B2080 | RN 1 dihydrochloride DataSheet

Alternate Name/Synonyms: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 1781835-13-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₉N₃O₂.2HCl

Molecular Weight: 452.42

Cell-Permeable?: Yes

Purity: ≥97%

Solubilities: DMSO (~8 mg/ml) or H₂O (~8 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor

MDL Number: N/A

PubChem CID: 90488995

SMILES: CN1CCN(CC1)C(=O)CNC2CC2C3=CC=C(C=C3)OCC4=CC=CC=C4.Cl.Cl

InChi: InChI=1S/C23H29N3O2.2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18;;/h2-10,21-22,24H,11-17H2,1H3;2*1H/t21-,22+;;/m0../s1

InChi Key: WMHAFZOOUBPQRX-VSIGASKDSA-N