RN185 Antibody (Center) [APR30681G]

RN185 Antibody (Center) [APR30681G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, Ha, M

Specificity: This RN185 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human RN185.

Cellular Localisation: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 20459

Clone: Polyclonal

Gene Name: RNF185

Gene ID: 91445

Function: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693) . Acts in the endoplasmic reticulum (ER) - associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036) . Protects cells from ER stress-induced apoptosis (PubMed:27485036) . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521) . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521) .

Summary: Tissue Location: Ubiquitously expressed.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: E3 ubiquitin-protein ligase RNF185, 632-, RING finger protein 185, RNF185