RNF166 Antibody (Center) [APR04590G]

RNF166 Antibody (Center) [APR04590G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This RNF166 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-97 amino acids from the Central region of human RNF166.

Cellular Localisation: Cytoplasm.

Molecular Weight: 26122

Clone: Polyclonal

Gene Name: RNF166

Gene ID: 115992

Function: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896) . In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896) . Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228) . Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896) . Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IF

Dilution: IF--1:25 WB--1:1000

Synonyms: RING finger protein 166, RNF166