BW
RNF185 polyclonal Antibody | BS72854
- SKU:
- BW-BS72854
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Description
RNF185 polyclonal Antibody | BS72854 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB 1:500 - 1:2000
Background: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693) . Acts in the endoplasmic reticulum (ER) -associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036) . Protects cells from ER stress-induced apoptosis (PubMed:27485036) . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521) . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521) .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: RNF185 polyclonal Antibody detects endogenous levels of RNF185 protein.
Molecular Weight: Refer to figures
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: N/A
Immunogen: Recombinant protein of human RNF185
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: