RNF185 polyclonal Antibody | BS72854

RNF185 polyclonal Antibody | BS72854 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693) . Acts in the endoplasmic reticulum (ER) -associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036) . Protects cells from ER stress-induced apoptosis (PubMed:27485036) . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521) . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RNF185 polyclonal Antibody detects endogenous levels of RNF185 protein.

Molecular Weight: Refer to figures

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: N/A

Immunogen: Recombinant protein of human RNF185

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: