RNF19B Antibody (Center) [APR03535G]

RNF19B Antibody (Center) [APR03535G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RNF19B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human RNF19B.

Cellular Localisation: Cytoplasmic granule membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 77925

Clone: Polyclonal

Gene Name: RNF19B

Gene ID: 127544

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036) . Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909) . Protects against staurosporin-induced cell death (PubMed:27485036) .

Summary: Tissue Location: Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10438909) . Present in natural killer cells (at protein level) (PubMed:10912506) Ubiquitously expressed with high expression in testis (PubMed:27485036) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:500 FC--1:10~50

Synonyms: E3 ubiquitin-protein ligase RNF19B, 632-, IBR domain-containing protein 3, Natural killer lytic-associated molecule, RING finger protein 19B, RNF19B, IBRDC3, NKLAM