RNT2 Antibody (N-term) [APR30673G]

RNT2 Antibody (N-term) [APR30673G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human RNT2.

Cellular Localisation: Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space. Note=Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction.

Molecular Weight: 29481

Clone: Polyclonal

Gene Name: RNASET2

Gene ID: 8635

Function: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653) . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2', 3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653) . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653) . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494) . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512) .

Summary: Tissue Location: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:500-1:1000 WB--1:1000 IHC-P--1:100~500

Synonyms: Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL