Ro 08-2750 | B3017

Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor p75(NTR). It inhibits NGF-induced cell death of SK-N-MC cells. It reverses NGF-induced decrease in β-catenin mRNA expression and decrease in migration of SKOV3 and OVCAR-3 ovarian cancer cells at a concentration 10 μM.

Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor p75(NTR). It inhibits NGF-induced cell death of SK-N-MC cells. It reverses NGF-induced decrease in β-catenin mRNA expression and decrease in migration of SKOV3 and OVCAR-3 ovarian cancer cells at a concentration 10 μM.

B3017 | Ro 08-2750 DataSheet

Alternate Name/Synonyms: 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde; 7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde; 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

Appearance: Orange solid

Formulation:

CAS Number: 37854-59-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₃H₁₀N₄O₃

Molecular Weight: 270.24

Cell-Permeable?: TRUE

Purity: >95%

Solubilities: ~2.7 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist of nerve growth factor (NGF)

MDL Number: MFCD09038552

PubChem CID: 17756791

SMILES: CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C

InChi: InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20)

InChi Key: JDEMVNYMYPJJIM-UHFFFAOYSA-N