RO-3306 | 2039

Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387.

RO-3306 is a selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387.

2039 | RO-3306 DataSheet

Alternate Name/Synonyms: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one

Appearance: Brown solid

Formulation: N/A

CAS Number: 872573-93-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃N₃OS₂

Molecular Weight: 351.45

Cell-Permeable?: Yes

Purity: ≥95% by NMR

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective CDK 1 inhibitor

MDL Number: N/A

PubChem CID: 44450571

SMILES: C1=CC2=C(C=CC(=C2)C=C3C(=O)N=C(S3)NCC4=CC=CS4)N=C1

InChi: InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+

InChi Key: XOLMRFUGOINFDQ-MHWRWJLKSA-N