Roflumilast | 2675

Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.8 nM). Displays anti-inflammatory properties.

Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.8 nM). Displays anti-inflammatory properties.

2675 | Roflumilast DataSheet

Alternate Name/Synonyms: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; B 9302-107; BY 217; BYK 20869; Daxas

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 162401-32-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄Cl₂F₂N₂O₃

Molecular Weight: 403.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective phosphodiesterase 4 (PDE4) inhibitor

MDL Number: MFCD00938270

PubChem CID: 449193

SMILES: C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F

InChi: InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChi Key: MNDBXUUTURYVHR-UHFFFAOYSA-N