RORA polyclonal Antibody | GCP103

RORA polyclonal Antibody | GCP103 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Pig

Application: WB

Application Range: WB: 1:5000~1:10000

Background: Retinoids are metabolites of vitamin A (retinol) and represent an important class of signaling molecule during vertebrate development and tissue differentiation. A large group of nuclear transcription factors, including vitamin D3 receptor (VDR), thyroid hormone receptor (TR), RAR, RXR and ecdysone receptor, have a high affinity for retinoic acids and are members of the steroid receptor superfamily. This family acts by directly associating with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. RORα is a member of the steroid receptor superfamily and is classified as an “orphan receptor” due to the lack of a defined ligand. Two isoforms of RORα have been described and are designated RORα1 and RORα2. RORα, also referred to as RZR, binds DNA as a monomer at consensus RORα response elements (ROREs) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RORA polyclonal Antibody detects endogenous levels of RORA protein.

Molecular Weight: ~ 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha; RORA; NR1F1, RZRA

Immunogen: Synthetic peptide, corresponding to Human RORA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A