Description
ROS1 Antibody [AMM22254G] | Gentaur UK, US & Europe Distribution
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H
Specificity: This ROS1 antibody is generated from a mouse immunized with a recombinant protein of human ROS1.
Cellular Localisation: Cell membrane; Single-pass type I membrane protein
Molecular Weight: 263915
Clone: Monoclonal
Gene Name: ROS1
Gene ID: 6098
Function: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Summary: Tissue Location: Expressed in brain. Expression is increased in primary gliomas.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:4000 IHC--1:250
Synonyms: Proto-oncogene tyrosine-protein kinase ROS, 2.7.10.1, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS