RPC5 Antibody (Center) [APR31852G]

RPC5 Antibody (Center) [APR31852G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241~271 amino acids from the central region of human RPC5.

Cellular Localisation: Nucleus.

Molecular Weight: 79898

Clone: Polyclonal

Gene Name: POLR3E

Gene ID: 55718

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: N/A

Dilution: N/A

Synonyms: DNA-directed RNA polymerase III subunit RPC5, RNA polymerase III subunit C5, DNA-directed RNA polymerase III 80 kDa polypeptide, POLR3E, KIAA1452