RPSA Antibody | 7605

RPSA Antibody | 7605 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: Predicted species reactivity based on immunogen sequence: Pig: (100%) , Bovine: (100%) , Chicken: (100%) , Rat: (100%) , Sheep: (100%)

Immunogen: RPSA antibody was raised against a 17 amino acid peptide near the carboxy terminus of human RPSA.
The immunogen is located within amino acids 190 - 240 of RPSA.

Research Area: Signal Transduction

Tested Application: E, WB, IHC-P, IF

Application: RPSA antibody can be used for detection of RPSA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: RPSA antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1223 - Caco-2 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 32 kDa
Observed: 32 kDa

Validation: N/A

Isoform: N/A

Purification: RPSA antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: RPSA antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: RPSA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: RPSA Antibody: SA, LBP, LRP, p40, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p40, NEM/1CHD4, 40S ribosomal protein SA, 37 kDa laminin receptor precursor

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1) . Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2) . RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3) .