RS-504393 | B2406

RS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.

RS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.

B2406 | RS-504393 DataSheet

Alternate Name/Synonyms: 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Appearance: Off-white solid

Formulation:

CAS Number: 300816-15-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₇N₃O₃

Molecular Weight: 417.5

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective CCR2 chemokine receptor antagonist

MDL Number:

PubChem CID: 9953769

SMILES: CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C

InChi: InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

InChi Key: ODNICNWASXKNNQ-UHFFFAOYSA-N