RTA 408 | B2860

RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7 macrophage cells at low concentrations (≤ 25 nM). It inhibits growth of tumor cells with a GI₅₀ value of 260 ± 74 nM. Topical application of RTA 408 induces cytoprotective genes and protects mice from radiation-induced dermatitis.

RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7 macrophage cells at low concentrations (≤ 25 nM). It inhibits growth of tumor cells with a GI₅₀ value of 260 ± 74 nM. Topical application of RTA 408 induces cytoprotective genes and protects mice from radiation-induced dermatitis.

B2860 | RTA 408 DataSheet

Alternate Name/Synonyms: N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide; Omaveloxolone; N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide; N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide

Appearance: A crystalline solid

Formulation:

CAS Number: 1474034-05-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₃₃H₄₄F₂N₂O₃

Molecular Weight: 554.71

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~2 mg/ml in ethanol, DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An activator of Nrf2

MDL Number:

PubChem CID: 71811910

SMILES: CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)NC(=O)C(C)(F)F)C

InChi: InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1

InChi Key: RJCWBNBKOKFWNY-IDPLTSGASA-N