RTN4 Antibody (N-Term) [APR13163G]

RTN4 Antibody (N-Term) [APR13163G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RTN4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-58 amino acids from human RTN4.

Cellular Localisation: [Isoform A]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Cytoplasmic side Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977) . Co-localizes with TMEM33 at the ER sheets [Isoform C]: Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 129931

Clone: Polyclonal

Gene Name: RTN4 (HGNC:14085)

Gene ID: 57142

Function: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037) . They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289) . They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412) . However each isoform have specific functions mainly depending on their tissue expression specificities (Probable) .

Summary: Tissue Location: Isoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:21183689) . Isoform C: is expressed in brain, skeletal muscle and adipocytes. Isoform D is testis-specific.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Reticulon-4, Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5, RTN4, KIAA0886, NOGO