RUNX1T1 Polyclonal Antibody | E-AB-67119

RUNX1T1 Polyclonal Antibody | E-AB-67119 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: RUNX1T1, AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2

Application: WB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human RUNX1T1 (NP_783554.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 44 kDa/48 kDa/63 kDa/64 kDa/67 kDa/68 kDa

Molecular Weight(Observed): 67 kDa