Ruxolitinib . phosphate salt | 10-043

Ruxolitinib . phosphate salt | 10-043 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 306.4 . 98.0

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: INCB018424; INC 424

Background: Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM) . Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)

Disclaimer: This product is for research use only.

Purity: greater than or equal to 98% (HPLC)

Formula: C17H18N6 . H3O4P

Source: N/A

Solubility: Soluble in DMSO (10mg/ml) .

InChi Key: JFMWPOCYMYGEDM-XFULWGLBSA-N

Smiles: N#CC[C@H] (C1CCCC1) N (N=C2) C=C2C3=NC=NC4=C3C=CN4.OP (O) (O) =O

RTECS: N/A

Identity: Determined by 1H-NMR and MS.

Merck Index: N/A