S100P polyclonal Antibody | BS91196

S100P polyclonal Antibody | BS91196 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC IP

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 IP:1:50-1:100

Background: S-100 proteins are small dimeric members of the EF-Hand superfamily that participate in moderating intracellular calcium signals by binding to and regulating specific proteins in a calcium-dependent manner. S-100P is a survival factor that is associated with different types of tumors and can bind and regulate effector proteins. R1881, a synthetic androgen, regulates S-100P expression. S-100P interacts with a receptor for advanced glycation end products (RAGE) and activates it, thereby increasing the rates of cell growth, division, migration and invasion. This suggests that S-100P acts in an auto-crine manner through RAGE to trigger cell proliferation and survival. S-100P may also positively affect anchorage-independent growth to improve tumor formation. S-100P monomers strongly interact with one another, but not with other S-100 polypeptides, suggesting that homodimer formation is necessary for S-100P to function. The S-100P dimers are then stabilized by hydrophobic contacts.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: S100P polyclonal Antibody detects endogenous levels of S100P protein.

Molecular Weight: 10 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MIG9, S100P, MIG9, Migration inducing gene 9, Protein S100-E, Protein S100-P, Protein S100P, S100 calcium binding protein P, S100 calcium-binding protein P, S100 P, S100E, S100P, S100P,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: