S1P/Subtilisin Polyclonal Antibody | BS65838

S1P/Subtilisin Polyclonal Antibody | BS65838 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Chicken,Rabbit,

Application: WB,

Application Range: WB=1:500-2000

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

Storage & Stability: Store at 4°C short term. Aliquot and store at -11°C long term. Avoid freeze-thaw cycles.

Specificity: S1P/Subtilisin Polyclonal Antibody detects endogenous levels of S1P/Subtilisin protein.

Molecular Weight: ~126 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: kexin isozyme 1; KIAA0091; MBTP1_HUMAN； MBTPS1; membrane bound transcription factor peptidase, site 1; MGC138711; MGC138712; PCSK8; S1P; S1P endopeptidase; Site 1 protease; SKI 1; SKI1; Subtilisin isozyme 1; Subtilisin/kexin isozyme 1.  

Immunogen: KLH conjugated synthetic peptide derived from human S1P/Subtilisin isozyme 1:861-960/1052

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: