SAE1 polyclonal Antibody | BS91199

SAE1 polyclonal Antibody | BS91199 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC

Application Range: WB:1:500-1:2,000 FC:1:50-1:100

Background: Proteolytic degradation by the ubiquitin (Ub) system is essential for normal cell cycle progression, cellular differentiation and stress responses. Proteins conjugated to Ub are marked for progressive degradation by the 26S Proteasome. AOS-1, also designated SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, belongs to the ubiquitin-activating E1 family of proteins and plays an important role in the first step of the UBL1 conjugation pathway. AOS-1, which is a dimeric enzyme, functions as a UBLI E1 ligase, mediating the ATP-dependent activation of UBL1. AOS-1 can bind with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SAE1 polyclonal Antibody detects endogenous levels of SAE1 protein.

Molecular Weight: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SAE1, AOS1, SUA1, UBLE1A, Activator of SUMO1, AOS1, HSPC140, Sae1, SAE1, Sentrin/SUMO activating protein AOS1, SUA1, SUMO 1 activating enzyme E1 N subunit, SUMO 1 activating enzyme subunit 1, SUMO-activating enzyme subunit 1, Ubiquitin like protein SUMO1 activating enzyme, Ubiquitin-like 1-activating enzyme E1A, UBL E1A, UBLE1A,

Immunogen: Recombinant protein within human SAE1 aa 150-300.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: