SAFB-1 monoclonal Antibody | MB0113

SAFB-1 monoclonal Antibody | MB0113 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB ICC

Application Range: WB: 1:1000~4000 ICC: 1:100~300

Background: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA) . This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a ´transcriptosome complex´ in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of SAFB-1 and does not cross-react with related proteins

Molecular Weight: Predicted band size:130kDa Observed band size:130kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HSP27 estrogen response element-TATA box-binding protein; HAP; HET; SAFB1; SAF-B1

Immunogen: Recombinant full length Human SAFB-1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: