SAG Antibody (C-Term) [APR13192G]

SAG Antibody (C-Term) [APR13192G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This SAG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-307 amino acids from the human SAG.

Cellular Localisation: Cell projection, cilium, photoreceptor outer segment. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity) Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866) {ECO:0000250|UniProtKB:P08168, ECO:0000269|PubMed:3720866}

Molecular Weight: 45120

Clone: Polyclonal

Gene Name: SAG

Gene ID: 6295

Function: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity) . May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049) .

Summary: Tissue Location: Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG