SAPCD2 Antibody (C-Term) [ApR04960G]

SAPCD2 Antibody (C-Term) [ApR04960G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SAPCD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 333-367 amino acids from human SAPCD2.

Cellular Localisation: Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis {ECO:0000250|UniProtKB:Q9D818}

Molecular Weight: 42637

Clone: Polyclonal

Gene Name: SAPCD2 (HGNC:28055)

Gene ID: 89958

Function: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity) . Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442) . Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824) .

Summary: Tissue Location: Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738) . Undetectable in non-cancerous adult tissues (PubMed:17525738) . Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738) . Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738) . Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Suppressor APC domain-containing protein 2, Tumor specificity and mitosis phase-dependent expression protein, TS/MDEP, p42.3, SAPCD2, C9orf140