SARS-CoV-2 RBD Neutralizing Antibody [7V816] | 11-088

SARS-CoV-2 RBD Neutralizing Antibody [7V816] | 11-088 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Virus

Homology: N/A

Immunogen: HEK293 derived SARS-COV-2 SPIKE RBD, amino acids Arg319-Phe541

Research Area: Infectious Disease, COVID-19

Tested Application: E

Application: N/A

Specificiy: SARS-CoV-2

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.

Clonality: Recombinant Monoclonal

Clone: 7V8I6

Isotype: Mouse IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied as a 0.2um filtered solution in PBS, pH 7.4.

Concentration: 1mg/ml

Storage Condition: This antibody can be stored at 2˚C to -8˚C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚C to -80˚C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Alternate Name: spike glycoprotein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD) , which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD) , leading to a higher mortality rate