SART1 Antibody | 23-663

SART1 Antibody | 23-663 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human SART1 (NP_005137.1) .

Research Area: Apoptosis, Cancer, Cell Cycle

Tested Application: WB, IP

Application: WB: 1:500 - 1:2000
IP: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: HeLa

Positive Control 2: Jurkat

Positive Control 3: HepG2

Positive Control 4: Mouse liver

Positive Control 5: Mouse brain

Positive Control 6: Mouse testis

Molecular Weight: Observed: 120kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: SART1, squamous cell carcinoma antigen recognised by T cells, ARA1, Ara1, HOMS1, MGC2038, SART1259, Snu66, IgE autoantigen, SART1 (259) protein, SART1 (800) protein, U4/U6.U5 tri-snRNP-associated 110 kDa protein, squamous cell carcinoma antigen recognized by T cells 1, SNRNP110

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes two proteins, the SART1 (800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1 (259) protein expressed in the cytosol of epithelial cancers. The SART1 (259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1 (259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1 (259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1 (259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.