SART1 polyclonal Antibody | BS71852

SART1 polyclonal Antibody | BS71852 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: This gene encodes two proteins, the SART1 (800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1 (259) protein expressed in the cytosol of epithelial cancers. The SART1 (259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1 (259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1 (259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1 (259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SART1 polyclonal Antibody detects endogenous levels of SART1 protein.

Molecular Weight: 120kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ara1; HOMS1; SART1259; SNRNP110; Snu66

Immunogen: Recombinant protein of human SART1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: