SASH1 Antibody (Center) [APR30808G]

SASH1 Antibody (Center) [APR30808G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This SASH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596-625 amino acids from the Central region of human SASH1.

Cellular Localisation: Cytoplasm.

Molecular Weight: 136653

Clone: Polyclonal

Gene Name: SASH1

Gene ID: 23328

Function: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175) . Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175) . Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659) . Regulates lipolysaccharide (LPS) -induced endothelial cell migration (PubMed:23776175) . Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244) .

Summary: Tissue Location: Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes (PubMed:23333244, PubMed:26203640) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:2000 IHC-P--1:100~500

Synonyms: SAM and SH3 domain-containing protein 1, Proline-glutamate repeat-containing protein, SASH1, KIAA0790, PEPE1