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SATB1 polyclonal Antibody | BS91208
- SKU:
- BW-BS91208
- Availability:
- Usually ships in 5 working days
Description
SATB1 polyclonal Antibody | BS91208 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP FC
Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: SATB1 polyclonal Antibody detects endogenous levels of SATB1 protein.
Molecular Weight: 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: SATB1, DNA binding protein SATB1, DNA-binding protein SATB1, SATB homeobox 1, SATB1, SATB1, Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA), Special AT rich sequence binding protein 1, Special AT-rich sequence-binding protein 1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: