SAV1 Antibody | 24-010

SAV1 Antibody | 24-010 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SAV1 (NP_068590.1) .

Research Area: Cell Cycle, Signal Transduction

Tested Application: WB

Application: WB: 1:1000 - 1:4000

Specificiy: N/A

Positive Control 1: HeLa

Positive Control 2: SKOV3

Positive Control 3: SW480

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 45kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: SAV1, salvador homolog 1 (Drosophila) , SAV, WW45, WWP4, 1700040G09Rik, WW domain-containing, WW45 protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1) -associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.