SBI-0206965 | 9580

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.

9580 | SBI-0206965 DataSheet

Alternate Name/Synonyms: 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₁BrN₄O₅

Molecular Weight: 489.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO >20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An autophagy kinase ULK1 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br

InChi: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)

InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N