SC-79 | 2766

SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.

SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.

2766 | SC-79 DataSheet

Alternate Name/Synonyms: 2-Amino-6-chloro-α-cyano-3-(ethoxyca­rbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 305834-79-1

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₇ClN₂O₅

Molecular Weight: 364.78

Cell-Permeable?: Y

Purity: ≥98% by TLC

Solubilities: DMSO (~ 100 mg/ml) or EtOH (~ 40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An Akt activator

MDL Number: N/A

PubChem CID: N/A

SMILES: ClC1=CC=C(OC(N)=C(C(OCC)=O)C2C(C#N)C(OCC)=O)C2=C1

InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChi Key: DXVKFBGVVRSOLI-UHFFFAOYSA-N