SCAF8 Antibody (Center) [APR33281G]

SCAF8 Antibody (Center) [APR33281G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SCAF8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 520-554 amino acids from the Central region of human SCAF8.

Cellular Localisation: Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription

Molecular Weight: 140519

Clone: Polyclonal

Gene Name: SCAF8 {ECO:0000303|PubMed:9528809, ECO:0000312|HGNC:HGNC:20959}

Gene ID: 22828

Function: Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839) . Together with SCAF4, acts by suppressing the use of early, alternative poly (A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839) . Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839) . Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein SCAF8, CDC5L complex-associated protein 7, RNA-binding motif protein 16, SR-related and CTD-associated factor 8, SCAF8, CCAP7, KIAA1116, RBM16