SCD1 Inhibitor | 1716

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.

SCD1 inhibitor is a potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1).

1716 | SCD1 Inhibitor DataSheet

Alternate Name/Synonyms: 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂ClN₃O₃

Molecular Weight: 387.86

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~ 180 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A SCD1(stearoyl-CoA desaturase 1 inhibitor

MDL Number: N/A

PubChem CID: 24905400

SMILES: CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl

InChi: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16 (10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23, 26)

InChi Key: DPYTYQFYDLYWHZ-UHFFFAOYSA-N