Sclerotiorin | 2334

An antibiotic Isolated from fungus Penicillium sp. Cholesteryl ester transfer protein (CETP) activity inhibitor (IC₅₀ = 19.4 µM). Weak antagonist of human endothelin receptor A (ETA) and B (ETB). A potent aldose reductase inhibitor and a potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Also acts as an antioxidant and a free radical scavenger.

Sclerotiorin is a cholesteryl ester transfer protein (CETP) activity inhibitor (IC₅₀ = 19.4 µM). Weak antagonist of human endothelin receptor A (ETA) and B (ETB). A potent aldose reductase inhibitor and a potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor.

2334 | Sclerotiorin DataSheet

Alternate Name/Synonyms: (S-(R*,R*-(E,E)))-Sclerotiorin

Appearance: Yellow solid

Formulation: N/A

CAS Number: 549-23-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₃ClO₅

Molecular Weight: 390.86

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antibacterial antibiotic

MDL Number: N/A

PubChem CID: 6436015

SMILES: CCC(C)C=C(C)C=CC1=CC2=C(C(=O)C(C(=O)C2=CO1)(C)OC(=O)C)Cl

InChi: InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1

InChi Key: SWJLTKXURNHVHE-UPWXJBBJSA-N