SCO1 polyclonal Antibody | BS8394

SCO1 polyclonal Antibody | BS8394 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: The SCO1 and SCO2 protein homologs belong to the SCO1/2 family of proteins. SCO1 and SCO2 both localize to the mitochondrion and are inner membrane proteins crucial for copper insertion or transport to the active site of cytochrome c oxidase (COX) . COX is a crucial component in energy production because it functions as the terminal enzyme in the respiratory chain. SCO1 is predominantly expressed in highly oxidative phosphorylation tissues such as brain, heart and muscle, while SCO2 is ubiquitously expressed. Defects in the gene encoding for SCO1 may cause cytochrome c oxidase deficiency, a hetero-genous disorder. Defects in the gene encoding for SCO2 may cause cardioencephalomyopathy with cytochrome c oxidase deficiency, a fatal infantile disorder characterized by hypertrophic cardiomyopathy, lactic acidosis and gliosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SCO1 polyclonal Antibody detects endogenous levels of SCO1 protein.

Molecular Weight: ~ 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Protein SCO1 homolog, mitochondrial; SCO1; SCOD1

Immunogen: Recombinant full length Human SCO1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: