SEC24D Antibody (N-Term) [AMM07745G]

SEC24D Antibody (N-Term) [AMM07745G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SEC24D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-266 amino acids from human SEC24D.

Cellular Localisation: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250|UniProtKB:P53992}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P53992}; Cytoplasmic side {ECO:0000250|UniProtKB:P53992}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P53992}

Molecular Weight: 113010

Clone: Polyclonal

Gene Name: SEC24D (HGNC:10706)

Gene ID: 9871

Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) . The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296) . Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296) . May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317) . May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296) .

Summary: Tissue Location: Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Protein transport protein Sec24D, SEC24-related protein D, SEC24D, KIAA0755